N-<wbr/>(3-<wbr/>pyridyl)-<wbr/>Indomethacin amide

N-(3-pyridyl)-Indomethacin amide

CAT N°: 70274
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From 26.00 22.10

N-(3-pyridyl)-indomethacin amide (N-3PyIA) is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2.{8243} N-3PyIA selectively inhibits human recombinant COX-2 with an IC50 of 0.052 µM. It is about 1,300 times less potent as an inhibitor of ovine recombinant COX-1.{8243} However, N-3PyIA is not selective as an inhibitor of ovine seminal vesicular COX-1 and ovine placental COX-2. The IC50 values for ovine COX-1 and -2 are 75 and 50 µM, respectively.{8513}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-(3-pyridyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetamide
  • Correlated keywords
    • aromatic amides inhibitors inhibits COX-2 COX2 PGHS2 PGHS-2 prostaglandin H synthases cyclooxygenases COX-1 COX1 PGHS1 PGHS 1
  • Product Overview:
    N-(3-pyridyl)-indomethacin amide (N-3PyIA) is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2.{8243} N-3PyIA selectively inhibits human recombinant COX-2 with an IC50 of 0.052 µM. It is about 1,300 times less potent as an inhibitor of ovine recombinant COX-1.{8243} However, N-3PyIA is not selective as an inhibitor of ovine seminal vesicular COX-1 and ovine placental COX-2. The IC50 values for ovine COX-1 and -2 are 75 and 50 µM, respectively.{8513}

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