€615.00 €522.75
Paired box (Pax) protein 5 (Pax5) is a transcription factor and member of the Pax family that functions as a transcriptional activator and repressor with an essential role in B cell development.{54577,54578} It is composed of a DNA-binding paired domain, conserved octapeptide, partial homeodomain, transactivation domain, and an inhibitory domain.{54577} PAX5 is exclusively expressed in hematopoietic stem cells committed to the B cell lineage. It is switched on during the transition from uncommitted pre-pro-B cells to committed B cells during lymphopoiesis, expressed throughout development to the mature B cell stage, and is repressed during terminal plasma cell differentiation. Pax5 downregulates expression of genes required for myeloid and T cell development, such as CSF1R and NOTCH1, and activates expression of genes encoding B cell receptor (BCR) signaling components, as well as regulatory and structural proteins involved in B cell migration, antigen presentation, signaling, adhesion, and germinal center B cell formation.{54577,54578} PAX5 knockdown inhibits VH-DJH recombination in pro-B cells. Intragenic amplification of PAX5 is associated with poor prognosis in B cell precursor acute lymphoblastic leukemia (BCP-ALL).{54579} Cayman’s Pax5 (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µl |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Host | Rabbit |
| Antigen | Peptide from the C-terminal region of human Pax5 |
| Clone | RM331 |
| Isotype | IgG |
| Application(s) | IHC, WB |
| Formulation | 100 µl of protein A-affinity purified monoclonal antibody |
| Custom code | 3822.19 |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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