24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid (Item No. 90010) by cytochrome P450 enzymes.{463,729} In solution, 5(6)-EET degrades into 5,6-DiHET and 5(6)-?-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS.{39654} In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5(6)-EET has been implicated in the mobilization of calcium and hormone secretion.{462,460} 5(6)-EET is an inhibitor of T-type voltage-gated calcium channels (Cav3) that inhibits isoforms Cav3.1, Cav3.2 (IC50 = 0.54 µM), and Cav3.3 and decreases nifedipine-resistant phenylephrine-induced vasoconstriction in isolated mouse mesenteric arteries via Cav3.2 blockade when used at a concentration of 3 µM.{42110} In addition, it is a substrate of COX-1 and COX-2, as measured by oxygen consumption and product formation assays when used at a concentration of 50 µM.{34481} (±)5(6)-EET is provided as a mixture of the free acid and lactone.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µg, 25 µg, 50 µg, 500 µg |
|---|---|
| Shipping | dry ice |
| CAS number | 87173-80-6 |
| Molecular formula | C20H32O3 |
| Smiles | CCCCC/C=CC/C=CC/C=CC[C@@H](O1)[C@@H]1CCCC(O)=O, CCCCC/C=CC/C=CC/C=CC[C@@H](O1)[C@@H]1CCCC(O)=O, CCCCC/C=CC/C=CC/C=CC[C@@H](O1)[C@@H]1CCCC(O)=O, CCCCC/C=CC/C=CC/C=CC[C@@H](O1)[C@@H]1CCCC(O)=O |
| Molecular weight | 320,5 |
| Custom code | 2910.90 |
| Formulation | A solution in ethanol |
| Purity | ≥95% (mixture of free acid and lactone) |
| UNSPSC code | 12352100 |
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