€615.00 €522.75
Acetyl-CoA carboxylase 1 (ACC1) is a biotin-dependent enzyme that catalyzes the conversion of acetyl-CoA (Item No. 16160) to malonyl-CoA (Item No. 16455), a building block in the biosynthesis of long-chain fatty acids.{60043,60044,60045} It is found at high levels in the liver and adipose tissue and is localized to the cytosol.{60045} Expression of ACC1 is increased by sterol regulatory element binding protein-1a (SREBP-1a) and SREBP-1c, which are induced by insulin, as well as the lipid precursors inositol and choline (Item No. 31178).{60043} ACC1 activity is increased by citrate and inhibited by binding to long-chain acyl-CoAs or by phosphorylation by a number of kinases, including AMPK and TAK1.{60043,60045,60046} Phosphorylation of ACC1 at serine 79 by AMPK inhibits the catalytic activities of ACC1, preventing the generation of malonyl-CoA, whereas dephosphorylation by protein phosphatase 4 promotes hepatic lipogenesis.{59583,59584} Knock-in mice with an alanine in place of serine at position 79 to prevent phosphorylation at this residue of Acc1 have increased de novo lipogenesis, reduced ?-oxidation, and increased insulin resistance and glucose intolerance.{59583} Cayman’s Acetyl-CoA Carboxylase 1 (Phospho-Ser79) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µl |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Host | Rabbit |
| Antigen | Peptide corresponding to human ACC1 (phospho-Ser79) |
| Clone | RM270 |
| Isotype | IgG |
| Application(s) | IHC, WB |
| Formulation | 100 µl of protein A-affinity purified monoclonal antibody |
| Custom code | 3822.19 |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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