JNJ-</wbr>37822681 (hydro</wbr>chloride)

JNJ-37822681 (hydrochloride)

CAT N°: 37428
Price:

66.00 56.10

JNJ-37822681 is a dopamine D2L receptor antagonist (Ki = 0.158 µM).{67179} It is selective for dopamine D2L receptors over dopamine D1 and D3, ?1-adrenergic, and histamine H1 receptors, and the serotonin (5-HT) receptor subtypes 5-HT2A and 5-HT2C in radioligand binding assays (Kis = >3, 1.159, >5, 4.931, 2.896, and >4 µM, respectively). JNJ-37822681 inhibits apomorphine-induced stereotypy and D-amphetamine-induced hyperlocomotion in rat models of psychosis (ED50s = 0.19 and 1 mg/kg, respectively).

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