€615.00 €522.75
STAT3 is a ubiquitously expressed transcription factor and member of the STAT protein family that has roles in a variety of cellular functions including proliferation, apoptosis, and differentiation, as well as innate and adaptive immunity and stem cell pluripotency.{59562,59553,59872} It contains N-terminal, coiled-coil, DNA binding, and linker domains that mediate nuclear translocation and export, as well as Src homology 2 (SH2) and C-terminal transactivation domains that are subject to phosphorylation.{59554,59560} Alternative splicing of STAT3 pre-mRNA leads to the formation of the full-length isoform STAT3?, as well as STAT3?, a truncated isoform that lacks a portion of the transactivation domain and is considered a dominant-negative regulator of STAT3 transcriptional activation.{59561} STAT3 signaling is inhibited by the negative regulator suppressor of cytokine signaling 3 (SOCS-3) and prevents excessive STAT3 activation.{59553} Phosphorylation of STAT3 at tyrosine 705 (Tyr705) is mediated by JAKs in response to stimulation with cytokines or growth factors and induces STAT3 dimerization and nuclear translocation, leading to STAT3-dependent gene transcription.{59553,59562} Tumor STAT3 (phospho-Tyr705) levels are increased in patients with squamous or renal cell carcinoma and are associated with metastasis.{59563,59564} Cayman’s STAT3?/? (Phospho-Tyr705) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µl |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Host | Rabbit |
| Antigen | Peptide corresponding to human STAT3?/? (phospho-Tyr705) |
| Clone | RM261 |
| Isotype | IgG |
| Application(s) | IHC, WB |
| Formulation | 100 µl of protein A-affinity purified monoclonal antibody |
| Custom code | 3822.19 |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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