CL4H6

CL4H6

CAT N°: 37279
Price:

From 60.00 51.00

CL4H6 is an ionizable cationic amino lipid (apparent pKa = 6.35) that has been used in the generation of lipid nanoparticles (LNPs).{65433} LNPs containing CL4H6 and encapsulating Factor VII-targeting siRNA decrease hepatic levels of Factor VII in mice. Intravenous administration of LNPs containing CL4H6 and encapsulating siRNA targeting CD45 accumulate in tumor-associated macrophages and encapsulating siRNAs targeting STAT3 and HIF-1? decrease tumor volume in OS-RC-2 renal cancer mouse xenograft models.{65434}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 9-octadecenoic acid, 1,1?-[7-[4-(dipropylamino)butyl]-7-hydroxy-1,13-tridecanediyl] ester
  • Correlated keywords
    • CL-4H6 CD-45 OS-RC2 OSRC-2 OSRC2 STAT-3 HIF1?
  • Product Overview:
    CL4H6 is an ionizable cationic amino lipid (apparent pKa = 6.35) that has been used in the generation of lipid nanoparticles (LNPs).{65433} LNPs containing CL4H6 and encapsulating Factor VII-targeting siRNA decrease hepatic levels of Factor VII in mice. Intravenous administration of LNPs containing CL4H6 and encapsulating siRNA targeting CD45 accumulate in tumor-associated macrophages and encapsulating siRNAs targeting STAT3 and HIF-1? decrease tumor volume in OS-RC-2 renal cancer mouse xenograft models.{65434}

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