€615.00 €522.75
p38 MAPK is a serine/threonine protein kinase and member of the MAPK family with roles in the regulation of immune responses and embryonic development, as well as cell differentiation, metabolism, and survival.{60066,60067} It exists as 4 isoforms, p38?, -?, -?, and -?, encoded by MAPK14, MAPK11, MAPK12, and MAPK13, respectively, in humans. p38? MAPK is ubiquitously expressed, with the highest levels of expression in the heart, skeletal muscle, and brain.{60066,60068} It is activated via dual phosphorylation of threonine 180 (Thr180) and tyrosine 182 (Tyr182) by the MAP2K kinases MKK3 and MKK6 in response to LPS or the production of inflammatory cytokines and induces signaling through protein kinases, transcription factors, and transcriptional regulators, among others.{60066,60067} Levels of activated p38? MAPK (p38? phospho-Thr180/Tyr182) are increased and positively correlated with apoptosis in DU145 and PC3 prostate cancer cells in response to cisplatin (Item No. 13119).{60070} p38? Phospho-Thr180/Tyr182 levels are also increased in adult rat ventricular monocytes during stimulated ischemia.{60071} Cayman’s p38? MAPK (Phospho-Thr180/Tyr182) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes p38? MAPK (phospho-Thr180/Tyr182) at approximately 38 kDa from human samples.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µl |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Host | Rabbit |
| Antigen | Peptide corresponding to human p38? MAPK (phospho-Thr180/Tyr182) |
| Clone | RM243 |
| Isotype | IgG |
| Application(s) | IHC, WB |
| Formulation | 100 µl of protein A-affinity purified monoclonal antibody |
| Custom code | 3822.19 |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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