From €168.00 €142.80
Cu/Zn Superoxide dismutase (Cu/Zn SOD) is an antioxidant enzyme that protects cells from oxidative stress by scavenging superoxide anions.{55250} It exists as a homodimer that is stabilized by a disulfide bond between the subunits. Each monomer is composed of a Greek key ?-barrel and an active site channel made up of a ?4/?5 loop, which interacts with the dimer interface and active site zinc, and an electrostatic loop, which facilitates superoxide entry into the copper-containing active site.{55251} Cu/Zn SOD is ubiquitously expressed and primarily localizes to the cytosol but has also been found in the nucleus, peroxisomes, lysosomes, and the intermembrane space of mitochondria.{65441,12502} It catalyzes the dismutation of superoxide to hydrogen peroxide and oxygen by alternating reduction and reoxidation of copper at the enzyme active site.{55250} Overexpression of SOD1 protects against increases in reactive oxygen species (ROS) and apoptosis in an in vitro model of renal ischemia induced by ATP depletion.{27265} In vivo, transgenic mice expressing the destabilized Cu/Zn SODG93A mutation exhibit impaired spinal cord mitochondrial respiration.{10639,64708} Mutations in SOD1 are associated with amyotrophic lateral sclerosis (ALS).{15491} Cayman’s Cu/Zn SOD Monoclonal Antibody can be used for flow cytometry (FC), immunoprecipitation (IP), and Western blot (WB) applications.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µl, 200 µl, 50 µl |
|---|---|
| Shipping | dry ice |
| Molecular weight | |
| Antigen | Recombinant human Cu/Zn SOD |
| Host | Mouse |
| Clone | 11 |
| Isotype | IgG2b |
| Custom code | 3822.19 |
| Application(s) | FC, IP, WB |
| Formulation | 50, 100, or 200 µl of protein A-affinity purified monoclonal antibody |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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