24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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LOR253 is an activator of the transcription factor Kruppel-like factor 4 (KLF4).{62832} It increases levels of KLF4 and induces apoptosis in HCC1187, HCC38, and MDA-MB-468 cancer cells when used at concentrations of 5 and 10 µM. It is cytotoxic in a panel of 16 acute myeloid leukemia (AML) and lymphoma cell lines (IC50s = 0.057-1.75 µM) and induces cell cycle arrest at the G0/G1 phase in MV4-11, KG-1, and EoL-1 cells.{62833} LOR253 (1 mg/kg) accelerates wound healing, as well as increases plasma levels of KLF4 and wound site myeloid-derived suppressor cell (MDSC) accumulation, in an ob/ob mouse model of diabetic wound healing.{62834}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 10 mg, 25 mg, 5 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 916151-99-0 |
| Molecular formula | C22H14FN5 |
| Smiles | FC1=CC2=C(NC(C)=C2C3=NC4=C(N3)C5=C(N=CC=C5)C6=C4C=CC=N6)C=C1 |
| Molecular weight | 367,4 |
| Custom code | 2933.99 |
| Formulation | A solid |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
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Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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