tcY-NH<sub>2</sub> (trifluoro<wbr/>acetate salt)

tcY-NH2 (trifluoroacetate salt)

CAT N°: 36758
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From 174.00 147.90

tcY-NH2 is a synthetic peptide antagonist of proteinase-activated receptor 4 (PAR4) that corresponds to amino acids 1-6 of the amino terminal tethered ligand sequence of mouse PAR4.{36396} It inhibits platelet aggregation induced by the PAR4 agonist AYPGKF-NH2 (Item No. 24258) in washed isolated rat platelets (IC50 = 95-190 µM), as well as induces relaxation of isolated rat aortic rings precontracted with phenylephrine and contraction of isolated rat gastric longitudinal muscle strips (EC50s = 64 and 1 µM, respectively). tcY-NH2 (400 µM) inhibits thrombin-induced migration of primary hepatocellular carcinoma (HCC) cells.{67050} It reduces myocardial infarct size as a percentage of the area at risk ex vivo in a isolated rat heart model of ischemia-reperfusion injury.{67051}

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