GDC-046

GDC-046

CAT N°: 36601
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GDC-046 is a tyrosine kinase 2 (TYK2) inhibitor (Ki = 4.8 nM).{68143} It is selective for TYK2 over JAK1, -2, and -3 (Kis = 83.8, 27.6, and 253 nM, respectively). GDC-046 selectively inhibits TYK2-mediated IL-12-induced phosphorylation of STAT4 over JAK1-mediated IL-6-induced phosphorylation of STAT3 and JAK2-mediated erythropoietin-induced phosphorylation of STAT5 in cell-based assays (EC50s = 380, 2,000, and 1,700 nM, respectively).

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 2,6-dichloro-N-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-benzamide
  • Correlated keywords
    • GDC046 JAK2 JAK3 IL12
  • Product Overview:
    GDC-046 is a tyrosine kinase 2 (TYK2) inhibitor (Ki = 4.8 nM).{68143} It is selective for TYK2 over JAK1, -2, and -3 (Kis = 83.8, 27.6, and 253 nM, respectively). GDC-046 selectively inhibits TYK2-mediated IL-12-induced phosphorylation of STAT4 over JAK1-mediated IL-6-induced phosphorylation of STAT3 and JAK2-mediated erythropoietin-induced phosphorylation of STAT5 in cell-based assays (EC50s = 380, 2,000, and 1,700 nM, respectively).

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