L-Pyroglutamic Acid

Territorial Availability: Available through Bertin Technologies only in France

• Synonyms
  • 5-oxo-L-proline
• Correlated keywords
  • 498-91-9 6886-28-8 16891-48-8 29222-42-2 87430-62-4 95650-42-3 312618-42-1 pGlu p Glu (-)-2-Pyrrolidone-5-carboxylic (-)-Pyroglutamic (2S)-5-Oxopyrrolidine-2-carboxylic (5S)-2-Oxopyrrolidine-5-carboxylic (S)-(-)-2-Pyrrolidone-5-carboxylic (S)-(-)-?-Butyrolactam-?-carboxylic (S)-2-Pyrrolidone-5-carboxylic (S)-5-Oxo-1H-pyrrolidine-2-carboxylic (S)-5-Oxo-2-pyrrolidinecarboxylic 2-L-Pyrrolidone-5-carboxylic 2-Oxopyrrolidine-5(S)-carboxylic 2-Pyrrolidinone-5-carboxylic 5-Carboxy-2-pyrrolidinone 5-Oxoproline 5-Pyrrolidinone-2-carboxylic L-5-Carboxy-2-pyrrolidinone L-5-Oxo-2-pyrrolidinecarboxylic L-5-Oxoproline L-Glutamic acid, ?-lactam L-Glutimic L-Glutiminic L-Pyroglutamic L-Pyroglutamine L-Pyrrolidinonecarboxylic L-Pyrrolidonecarboxylic Ajidew A 100 Glutimic Glutiminic NSC143034 Oxoproline Oxopyrrolidinecarboxylic PCA 50 PCA50 Pidolidone Pyroglutamic Pyroglutamine Pyrrolidinonecarboxylic Pyrrolidone-5-carboxylic Pyrrolidonecarboxylic Take Off Booster VLS 3000-01 VLS3000 300001 VLS300001 L-Pidolic Acid (S)-Pyroglutamic Acid 2-Pyrrolidone-5-carboxylic Acid L-Pyrrolidone Carboxylic Acid
• Product Overview:
  L-Pyroglutamic acid is a cyclized form of L-glutamic acid (Item No. 30377). It is formed from L-glutamic acid or L-glutamine (Item No. 23716) by glutaminyl cyclase.{64496} A pyroglutamic acid-containing amyloid-? (A?) peptide (pGlu-A? (3-42)) aggregates at a higher rate than A? (3-42) and A?42 (Item No. 20574) when used at a concentration of 10 µM. It is a component of the neuropeptide adipokinetic hormone (AKH) in insects, a hormone that stimulates fatty acid oxidation during flight to provide energy.{64497} L-Pyroglutamic acid (500 mg/kg) increases the number of received shocks in the Vogel punished drinking task, indicating anxiolytic-like activity, in rats.{64498} Plasma levels of L-pyroglutamic acid are increased in patients with end-stage renal disease and pGlu-containing A? plaques have been found in brain tissue from patients with Alzheimer’s disease.{58132,64499} L-Pyroglutamic acid has been used in the synthesis of fibroblast activation protein (FAP) inhibitors.{58133}