AG-270

AG-270

CAT N°: 36246
Price:

From 336.00 285.60

AG-270 is an inhibitor of methionine adenosyltransferase 2A (MAT2A; IC50 = 0.014 µM).{67169} It reduces levels of S-(5′-adenosyl)-L-methonine (SAM; Item Nos. 16376 | 17595) in, and inhibits the proliferation of, HCT116 cells with a homozygous deletion of MTAP, the gene encoding methylthioadenosine phosphorylase (IC50s = 0.2 and 0.257 µM, respectively). AG-270 (200 mg/kg) reduces intratumor SAM levels and tumor growth in KP4 and HCT116 MTAP-null, but not HCT116 MTAP-wild-type, mouse xenograft models.

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