ARC 239 (hydro<wbr/>chloride)

ARC 239 (hydrochloride)

CAT N°: 36218
Price:

From 43.00 36.55

ARC 239 is an antagonist of ?2B-adrenergic receptors (?2B-ARs; Ki = 87.1 nM).{64516,64517,64518} It is selective for ?2B-ARs over ?2A-ARs (Ki = 3,548 nM) but also inhibits ?2C-ARs (Ki = 112.2 nM) and the serotonin (5-HT) receptor subtype 5-HT1A (Ki = 63.1 nM).{64517,64518} ARC 239 also binds to ?1A-, ?1B-, and ?1D-adrenergic receptors (Kds = 0.45, 7.08, and 1.82 nM, respectively) but only induces the release of intracellular calcium in CHO cells expressing the ?1B-adrenergic receptors with an EC50 value of 100 µM.{64519} It has commonly been used to determine the selectivity of ?2-adrenergic receptor agonists and antagonists.{64520,64521}

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