1,3-Dimethyluric Acid

1,3-Dimethyluric Acid

CAT N°: 36167
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From 100.00 85.00

1,3-Dimethyluric acid is an active metabolite of the methylxanthine alkaloids caffeine (Item No. 14118) and theophylline (Item No. 23760).{57870} It is formed from caffeine and theophylline by the cytochrome P450 (CYP) isoforms CYP1A2 and CYP2E1.{68171,68169} 1,3-Dimethyluric acid (500 µM) scavenges hydroxyl radicals in a cell-free assay and inhibits t-butyl hydroperoxide-induced lipid peroxidation by 77% in isolated human erythrocyte membranes.{58129} It induces contractions in isolated rabbit duodenal, jejunal, and ileal preparations, but induces relaxation in isolated rabbit ascending colon preparations, in a concentration-dependent manner.{68170} Intracerebral administration of 1,3-dimethyluric acid induces clonic convulsions in mice (ED50 = 360 nmol/animal).{60652} It has been found in urinary caliculi.{33336}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 7,9-dihydro-1,3-dimethyl-1H-purine-2,6,8(3H)-trione
  • Correlated keywords
    • 7026-70-2 NSC95854 Ba 2751 Oxytheophylline 13U CYP1A2 CYP 2E1 Ba2751
  • Product Overview:
    1,3-Dimethyluric acid is an active metabolite of the methylxanthine alkaloids caffeine (Item No. 14118) and theophylline (Item No. 23760).{57870} It is formed from caffeine and theophylline by the cytochrome P450 (CYP) isoforms CYP1A2 and CYP2E1.{68171,68169} 1,3-Dimethyluric acid (500 µM) scavenges hydroxyl radicals in a cell-free assay and inhibits t-butyl hydroperoxide-induced lipid peroxidation by 77% in isolated human erythrocyte membranes.{58129} It induces contractions in isolated rabbit duodenal, jejunal, and ileal preparations, but induces relaxation in isolated rabbit ascending colon preparations, in a concentration-dependent manner.{68170} Intracerebral administration of 1,3-dimethyluric acid induces clonic convulsions in mice (ED50 = 360 nmol/animal).{60652} It has been found in urinary caliculi.{33336}

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