FLT3-IN-3

FLT3-IN-3

CAT N°: 36106
Price:

From 263.00 223.55

FLT3-IN-3 is an inhibitor of FMS-related tyrosine kinase 3 (FLT3).{61858} It inhibits wild-type, FLT3D835Y, and FLT3 bearing internal-tandem duplication (FLT3-ITD; IC50s = 13, 8, and 3 nM, respectively). FLT3-IN-3 suppresses the growth of MV4-11 acute myeloid leukemia (AML) cells that express FLT3-ITD (GI50 = 7 nM). It induces cell cycle arrest at the G1 phase and apoptosis in the same cells. FLT3-IN-3 (10 mg/kg) reduces intratumor FLT3-ITD autophosphorylation in a MV4-11 mouse xenograft model.

We also advise you