SARS-CoV-2 Spike Glycoprotein S1 Subunit

Territorial Availability: Available through Bertin Technologies only in France

• Correlated keywords
  • anti-viral SARS-CoV-2 SARSCoV2 covid-19 covid19 coronavirus corona virus 2019nCoV glyco-protein S1RBD S1RBP CoV2 HEK-293 ACE-2 MERSCoV
• Product Overview:
  Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) surface glycoprotein, also known as the spike glycoprotein, is encoded by the S gene in SARS-CoV-2 RNA.{53462} SARS-CoV-2 is a member of the Betacoronavirus genus of viruses that has an approximately 79% sequence identity with SARS-CoV.{53459,53461} The spike protein of SARS-CoV-2 and the related viruses SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV) is a transmembrane glycoprotein that assembles into homotrimers on the virus surface and is comprised of an N-terminal S1 subunit, which contains the receptor binding domain (RBD), and a C-terminal S2 subunit, which facilitates fusion between viral and host cell membranes.{46767,46768,49561} The 193-amino acid RBD of the SARS-CoV spike protein is a target for neutralizing antibodies.{46768,49525} The SARS-CoV-2 RBD, which spans amino acid residues 329 to 521, is 73% identical to that of SARS-CoV and can bind to human angiotensin-converting enzyme 2 (ACE2), which is the host cell surface receptor for both SARS-CoV and SARS-CoV-2.{46767,46768, 49561,49525} SARS-CoV-2 is the causative agent of COVID-19, a primarily respiratory illness characterized by fever, cough, and shortness of breath that can lead to life-threatening complications.{53461,55257,55258} Cayman’s SARS-CoV-2 Surface Glycoprotein S1 Subunit can be used for ELISA. This protein is a disulfide-linked homodimer. The reduced monomer, comprised of the SARS-CoV-2 surface glycoprotein S1 subunit (amino acids 16-685) fused to mouse IgG1 Fc at its C-terminus, consists of 904 amino acids and has a calculated molecular weight of 101.4 kDa. As a result of glycosylation, the monomer migrates at approximately 116 kDa by SDS-PAGE under reducing conditions.