JPH203 (hydrochloride)

JPH203 (hydrochloride)

CAT N°: 36053
Price:

From 134.00 113.90

JPH203 is an inhibitor of L-type amino acid transporter 1 (LAT1; IC50 = 0.14 ?M for 14C-leucine uptake in S2 cells expressing the human transporter).{52371} It is selective for LAT1 over LAT2 (IC50 = >10 ?M). JPH203 inhibits 14C-leucine uptake by, and growth of, HT-29 cells (IC50s = 0.06 and 4.1 ?M, respectively). It induces apoptosis and increases levels of cleaved caspase-3, caspase-7, caspase-9, and poly(ADP-ribose) polymerase (PARP) in YD-38 oral cancer cells when used at a concentration of 3 mM.{52372} JPH203 (6.3, 12.5, and 25 mg/kg) reduces tumor growth in an HT-29 mouse xenograft model.{52371}

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