Isosinensetin

Isosinensetin

CAT N°: 36009
Price:

60.00 51.00

Isosinensetin is a polymethoxylated flavone that has been found in C. reticulata and has anticancer and anti-inflammatory activities.{47468,64547,64548} It inhibits P-glycoprotein (P-gp; IC50 = 4.2 µM) and increases the cytotoxicity of paraquat in MDR1-MDCKII cells and paclitaxel (Item No. 10461) in MX-1 breast and paclitaxel-resistant MX-1/T cancer cells.{47468} Isosinensetin inhibits the proliferation of A549 lung, HL-60 leukemia, MCF-7 breast, and HO-8910 ovarian cancer cells (IC50s = 23.6, 23.8, 15.1, and 12.5 µM, respectively).{64547} It prevents decreases in cell viability and inhibits increases in IL-1?, TNF-?, and IL-6 levels and the production of reactive oxygen species (ROS) induced by fine particulate matter less than or equal to 2.5 µm (PM2.5) in 16HBE bronchial epithelial cells when used at a concentration of 80 µg/ml.{64548}

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