Yamogenin

Yamogenin

CAT N°: 36008
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Yamogenin is a steroidal sapogenin that has been found in fenugreek (T. foenum graecum) and has diverse biological activities.{64666,64667} It inhibits activation of the liver X receptor (LXR) induced by the LXR? and LXR? agonist T0901317 (Item No. 71810) in HepG2 cells in a reporter assay when used at concentrations of 5 or 10 µM.{64666} Yamogenin (10 µM) decreases triglyceride levels in primary mouse hepatocytes. It is cytotoxic to HaCaT keratinocytes, as well as HeLa cervical and SKOV3 ovarian cancer cells (IC50s = 16.4, 19.6, and 23.9 µg/ml, respectively).{64667}

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