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Exendin-4 (5-39) amide is a 34-amino acid synthetic peptide corresponding to residues 5-39 of exendin-4 (48-86) amide (Item No. 11096) and an antagonist of the glucagon-like peptide 1 (GLP-1) receptor (IC50 = 0.3 nM) that has roles in synaptic transmission.{67094} It decreases GLP-1-induced increases in intracellular cAMP levels in CHO/pancGLPR cells. Exendin-4 (5-39) amide (10 and 100 nM) increases extracellular glutamate reuptake in primary rat hippocampal astrocytes.{67093} In vivo, exendin-4 (5-39) amide increases excitatory amino acid transporter 2 (EAAT2) protein levels and decreases the field excitatory postsynaptic potential decay time in the rat dentate gyrus when administered intracerebroventricularly.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 500 µg |
|---|---|
| Shipping | dry ice |
| Molecular formula | C169H262N44O54S • XCF3COOH |
| Smiles | OC(C[C@H](NC([C@H](CO)NC([C@]([H])([C@@H](C)O)NC([C@@H](NC([C@@]([C@H](O)C)([H])N[H])=O)CC1=CC=CC=C1)=O)=O)=O)C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CCCCN[H])C(N[C@@H](CCC(N)=O)C(N[C@@H](CCSC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@@](C(N[C@@H](CCC(O)=O)C(N[C@@H](CC2=CNC3=C2C=CC=C3)C(N[C@H](C(N[C@@H](CCCCN[H])C(N[C@@H](CC(N)=O)C(NCC(NCC(N4CCC[C@H]4C(N[C@@H](CO)C(N[C@@H](CO)C(NCC(N[C@H](C(N5CCC[C@H]5C(N6CCC[C@H]6C(N7CCC[C@H]7C(N[C@@H](CO)C(N)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC(C)C)=O)=O)=O)([H])[C@H](CC)C)=O)CC8=CC=CC=C8)=O)CC(C)C)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)CC(C)C)=O)=O.O=C(O)C(F)(F)F |
| Molecular weight | 3806,2 |
| Custom code | 3504.00 |
| Formulation | A solid |
| Purity | ≥95% |
| UNSPSC code | 12352100 |
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