Hygromycin A

Hygromycin A

CAT N°: 35565
Price:

From 43.00 36.55

Hygromycin A is an antibiotic originally isolated from S. hygroscopicus.{62571} It is active against numerous spirochete bacteria, including T. pallidum, L. biflexa, and four strains of B. burgdorferi (MICs = 0.03-4 µg/ml for all). Hygromycin A binds to the peptidyl transferase center (PTC) in the 70S ribosomal subunit to inhibit protein synthesis. It completely eliminates bacterial infection in skin biopsies from B. burgdorferi-infected mice in a model of acute Lyme disease when administered at doses ranging from 50 to 250 mg/kg twice per day.

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