Primin

Primin

CAT N°: 35441
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Primin is a benzoquinone that has been found in P. obconica and has diverse biological activities.{61951,61952,61953,61954} It selectively inhibits COX-2 over COX-1 (IC50s = 0.09 and 5.14 µM, respectively) and induces the production of adrenochrome from epinephrine, a marker of pro-oxidant activity, in a cell-free assay when used at a concentration of 8.81 µM.{61951} Primin is active against T. brucei rhodesiense and L. donovani (IC50s = 0.144 and 0.711 µM, respectively), as well as S. aureus (IC50 = 8.94 µM).{61952,61953} In vivo, primin induces contact sensitization in guinea pigs.{61954}

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