Gap 27 (trifluoro<wbr/>acetate salt)

Gap 27 (trifluoroacetate salt)

CAT N°: 35124
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Gap 27 is a connexin-mimetic peptide that corresponds to amino acids 204-214 of extracellular loop 2 in connexin 43.{64126} It reduces survival of isolated rat osteoclasts when used at a concentration of 500 µM and decreases bone resorption in rat bone slice and osteoclast co-cultures.{64127} Gap 27 accelerates wound closure and stratification of the corneal epithelium in isolated human corneas.{64128} In vivo, Gap 27 reduces cardiac remodeling and the incidence of cardiac arrhythmias in a rat model of arterio-venous fistula (AV-shunt) surgery-induced high-output heart failure.{64129}

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