€604.00 €513.40
Citrulline is a noncoding amino acid that is produced by deimination of arginine through the post-translational modification citrullination.{56025} Citrullination is catalyzed by protein arginine deiminases (PADs) that convert positively charged arginine to electrically neutral citrulline, decreasing the isoelectric point of the protein, altering the native protein structure, and influencing protein ionic interactions.{56026} Protein citrullination has roles in many physiological and pathological processes, including autoimmunity, cancer, and neurodegenerative disorders.{56027} Citrullination of arginine 26 on histone H3 by PAD2 (Item No. 10785) displaces histone H3 from chromatin, resulting in chromatin decondensation and estrogen receptor ? (ER?) transcriptional activation in a reporter assay.{30729} Citrullinated histones are also a component of neutrophil extracellular traps (NETs), a network of decondensed DNA and intracellular proteins secreted by neutrophils as a pathogen defense mechanism that is also a source of citrullinated autoantigens.{25917} Increased levels of antibodies to citrullinated protein antigens (ACPAs) are associated with increased disease severity in patients with rheumatoid arthritis.{56028} Plasma levels of citrullinated histone H3 are increased in patients with advanced cancer, and citrullinated glial fibrillary acidic protein (citGFAP; Item No. 28622) has been found in postmortem hippocampus from patients with Alzheimer’s disease.{56029,53021} Cayman’s Anti-Citrulline Monoclonal Antibody (Clone 1D9) can be used for ELISA, immunohistochemistry (IHC), and immunoprecipitation (IP) applications.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µg |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Host | Mouse |
| Antigen | Citrulline-containing peptide conjugated to keyhole limpet hemocyanin |
| Clone | 1D9 |
| Isotype | IgG2b |
| Application(s) | ELISA, IHC, IP |
| Formulation | 100 µg of protein G-purified monoclonal antibody |
| Custom code | 3822.19 |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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