Chikusetsusaponin IVa

Chikusetsusaponin IVa

CAT N°: 34832
Price:

From 66.00 56.10

Chikusetsusaponin IVa is an oleanane-type triterpenoid that has been found in P. stipuleanatus and has diverse biological activities.{58732,58733,58734} It inhibits the growth of human HL-60 leukemia and HCT116 colon cancer cells (IC50s = 76.23 and 78.11 µM, respectively).{58732} Chikusetsusaponin IVa (50-200 µg/ml) reduces LPS-induced increases in inducible nitric oxide synthase (iNOS), COX-2, IL-1?, IL-6, and TNF-? levels in THP-1 macrophages differentiated with phorbol 12-myristate 13-acetate (PMA; Item No. 10008014).{58733} It decreases plasma glucose, triglyceride, and LDL-cholesterol, and increases HDL-cholesterol, levels in a rat model of type 2 diabetes induced by streptozotocin (STZ; Item No. 13104) and a high-fat diet when administered at doses ranging from 45 to 180 mg/kg.{58734} It also decreases malondialdehyde (MDA), and increases superoxide dismutase (SOD), glutathione (GSH), and glutathione peroxidase 4 (GPX4), levels in the pancreas in the same model.

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