Adenosine 5'-methylenedi<wbr/>phosphate (hydrate)

Adenosine 5′-methylenediphosphate (hydrate)

CAT N°: 34504
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From 74.00 62.90

Adenosine 5′-methylenediphosphate is an inhibitor of ecto-5’-nucleotidase, also known as CD73, with a Ki value of 37 nM.{62213} It inhibits cAMP accumulation induced by adenosine 5′-monophosphate (AMP; Item No. 21094), adenosine 5′-diphosphate (ADP; Item Nos. 16778 | 21121), or adenosine 5′-triphosphate (ATP; Item No. 14498) but not adenosine (Item No. 21232) in VA-13 human fibroblasts when used at a concentration of 100 µM. Adenosine 5′-methylenediphosphate reduces proliferation of U138MG glioma cells, as well as inhibits the invasion and migration of MHCC97H hepatocellular carcinoma (HCC) cells in a migration assay.{62214,62215} It increases tumor infiltration of CD3+CD8+ T cells and reduces tumor growth in a K1735 murine melanoma model when administered at a dose of 400 µg/mouse.{62216}

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