GSK-A1

GSK-A1

CAT N°: 34502
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From 48.00 40.80

GSK-A1 is an inhibitor of phosphatidylinositol 4-kinase III? (PI4KIII?; IC50 = 3.16 nM).{61477} It is selective for PI4KIII? over PI4KIII?, PI3K?, PI3K?, and PI3K? (IC50s = >50 nM) but also inhibits PI3K? (IC50 = 15.8 nM). GSK-A1 decreases the levels of phosphatidylinositol 4-phosphate (PtdIns-(4)-P1) but not PtdIns-(4,5)-P2 in HEK293 cells expressing the angiotensin II type 1 (AT1) receptor (IC50 = 3 nM). GSK-A1 inhibits hepatitis C virus (HCV) genotype 1a and 1b replication.

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