Ac-FLTD-CMK (trifluoroacetate salt)

Ac-FLTD-CMK (trifluoroacetate salt)

CAT N°: 34469
Price:

From 641.00 544.85

Ac-FLTD-CMK is an inhibitor of caspase-1, -4, -5, and -11.{61775} It inhibits caspase-1, -4, and -5 (IC50s = 0.0467, 1.49, and 0.329, respectively, for the recombinant human enzymes) and cleavage of gasdermin D (GSDMD), an effector involved in pyroptosis and NETosis, by mouse caspase-11 when used at a concentration of 10 µM. Ac-FLTD-CMK (10 µM) inhibits LPS- and ATP- or LPS- and nigericin-induced pyroptosis and IL-1? release in mouse bone marrow-derived macrophages (BMDMs).

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