Bufotalin

Bufotalin

CAT N°: 34466
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48.00 40.80

Bufotalin is a bufadienolide that has been found in toad (B. asiaticus) venom and has cytotoxic and immunomodulatory activities.{57782,57781} It induces cell cycle arrest at the G1 phase and apoptosis in Hep3B cells when used at concentrations ranging from 0.13 to 1.13 µM.{57782} Bufotalin (100 µg/kg) reduces autoantibody production, serum levels of TNF-?, IL-1?, IFN-?, IL-22, and IL-17, and the number of splenic and lymph node Th17 cells, as well as increases saliva flow rates in a mouse model of experimental Sjörgren’s syndrome, an autoimmune disease characterized by the reduced secretion of exocrine glands.{57781} It also induces lethality in anesthetized dogs (LD50 = 0.36 mg/kg).{57780}

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