3-Methylxanthine

3-Methylxanthine

CAT N°: 34288
Price:

From 55.00 46.75

3-Methylxanthine is a cGMP phosphodiesterase (PDE) inhibitor and a metabolite of theophylline (Item No. 23760) and caffeine (Item No. 14118).{60649,60650,60651} It is formed from theophylline by the cytochrome P450 (CYP) isoform CYP1A2 and from caffeine via 6A5NF-1,3-dimethyluracil, 1,3,7-trimethyluric acid, or theobromine intermediates. 3-Methylxanthine inhibits cGMP PDE in isolated guinea pig trachealis muscle with an IC50 value of 920 µM.{60649} It is neurotoxic to mice, inducing convulsions with an ED50 value of 1,107 nmol/kg.{60652}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 3,9-dihydro-3-methyl-1H-purine-2,6-dione
  • Correlated keywords
    • Methyl-xanthine NSC515466 3MX 2,6-Dihydroxy-3-methylpurine CYP450 P-450 1A2 3MTX
  • Product Overview:
    3-Methylxanthine is a cGMP phosphodiesterase (PDE) inhibitor and a metabolite of theophylline (Item No. 23760) and caffeine (Item No. 14118).{60649,60650,60651} It is formed from theophylline by the cytochrome P450 (CYP) isoform CYP1A2 and from caffeine via 6A5NF-1,3-dimethyluracil, 1,3,7-trimethyluric acid, or theobromine intermediates. 3-Methylxanthine inhibits cGMP PDE in isolated guinea pig trachealis muscle with an IC50 value of 920 µM.{60649} It is neurotoxic to mice, inducing convulsions with an ED50 value of 1,107 nmol/kg.{60652}

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