Nefazodone-d<sub>6</sub> (hydro<wbr/>chloride)

Nefazodone-d6 (hydrochloride)

CAT N°: 34264
Price:

From 159.00 135.15

Nefazodone-d6 (hydrochloride) is intended for use as an internal standard for the quantification of nefazodone (Item No. 10012642) by GC- or LC-MS. Nefazodone is a serotonin (5-HT), norepinephrine, and dopamine reuptake inhibitor (SNDRI; Kis = 137, 570, 2,380 nM, respectively, in rat brain synaptosomes).{63036} It is also an antagonist of 5-HT2A, 5-HT1A, and histamine H1 receptors, as well as ?1- and ?2-adrenergic receptors (?2-ARs; Kis = 7.1, 52, 30, 5.5, and 84 nM, respectively).{32156} Nefazodone (100 mg/kg) reduces immobility time in the tail suspension test in gerbils.{63037} However, it is toxic to isolated human hepatocytes in a cultured sandwich hepatocyte preparation when used at a concentration of 30 µM.{63038} Formulations containing nefazodone have previously been used in the treatment of depression.

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