Alpidem

Alpidem

CAT N°: 34252
Price:

From 92.00 78.20

Alpidem is an anxiolytic agent.{58519} It selectively binds to ?1?2?2 subunit-containing GABAA receptors over ?5?2?2 subunit-containing GABAA receptors in HEK293 cells (IC50s = 0.017 and ?10 µM, respectively, for the recombinant rat receptors).{58520} Alpidem also binds to the GABAA/benzodiazepine receptor complex and translocator protein 18 kDa (TSPO) with IC50 values of 0.028 and 0.0079 µM, respectively.{58521} It reduces marble burying in mice, indicating anxiolytic activity, with a minimum effective dose (MED) of 10 mg/kg.{58522} Unlike the benzodiazepine alprazolam, alpidem does not induce sedation in mice when administered at doses up to 2 mg/kg.{58523} Formulations containing alpidem have previously been used in the treatment of generalized anxiety disorder.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 6-chloro-2-(4-chlorophenyl)-N,N-dipropyl-imidazo[1,2-a]pyridine-3-acetamide
  • Correlated keywords
    • ?1 ?2 ?2 GABA A ?5 HEK 293 Ananxyl SL 80.0342-00
  • Product Overview:
    Alpidem is an anxiolytic agent.{58519} It selectively binds to ?1?2?2 subunit-containing GABAA receptors over ?5?2?2 subunit-containing GABAA receptors in HEK293 cells (IC50s = 0.017 and ?10 µM, respectively, for the recombinant rat receptors).{58520} Alpidem also binds to the GABAA/benzodiazepine receptor complex and translocator protein 18 kDa (TSPO) with IC50 values of 0.028 and 0.0079 µM, respectively.{58521} It reduces marble burying in mice, indicating anxiolytic activity, with a minimum effective dose (MED) of 10 mg/kg.{58522} Unlike the benzodiazepine alprazolam, alpidem does not induce sedation in mice when administered at doses up to 2 mg/kg.{58523} Formulations containing alpidem have previously been used in the treatment of generalized anxiety disorder.

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