THPP-1

THPP-1

CAT N°: 34219
Price:

From 122.00 103.70

THPP-1 is an inhibitor of phosphodiesterase 10A (PDE10A; Ki = 1 nM).{58532} It is selective for PDE10A over PDE1A-9A and PDE11A (Kis = 44->50,000 nM for all). THPP-1 (3 mg/kg) decreases the number of avoidances in the conditioned avoidance response test in rats and reduces MK-801-induced increases in locomotor activity in mice.{58533} It improves novel object recognition in rats when administered at doses of 0.3 and 1 mg/kg.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • [2-(6-chloro-3-pyridinyl)-7,8-dihydro-4-(2-methoxyethoxy)pyrido[4,3-d]pyrimidin-6(5H)-yl]imidazo[1,5-a]pyridin-1-yl-methanone
  • Correlated keywords
    • THPP1 PDE 10A PDE1A9A PDE 11A MK801
  • Product Overview:
    THPP-1 is an inhibitor of phosphodiesterase 10A (PDE10A; Ki = 1 nM).{58532} It is selective for PDE10A over PDE1A-9A and PDE11A (Kis = 44->50,000 nM for all). THPP-1 (3 mg/kg) decreases the number of avoidances in the conditioned avoidance response test in rats and reduces MK-801-induced increases in locomotor activity in mice.{58533} It improves novel object recognition in rats when administered at doses of 0.3 and 1 mg/kg.

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