Phosphoramide Mustard (cyclohexylammonium salt)

Phosphoramide Mustard (cyclohexylammonium salt)

CAT N°: 34078
Price:

From 165.00 140.25

Phosphoramide mustard is an alkylating agent and active metabolite of cyclophosphamide (Item No. 13849).{58492} It is formed from cyclophosphamide via the ring-opened tautomer of the cytochrome P450 (CYP) isoform-formed intermediate 4-hydroxycyclophosphamide.{58494} Phosphoramide mustard induces DNA crosslinking, alkylates guanine in DNA, and increases the production of covalent DNA-protein conjugates in, and is cytotoxic to, HT-1080 human fibrosarcoma cells in a concentration-dependent manner. It is toxic to adult mice and teratogenic to embryos when administered to pregnant dams at a dose of 154 mg/kg on day 11 of gestation.{58493}

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