Diquafosol (sodium salt)

Diquafosol (sodium salt)

CAT N°: 33971
Price:

From 159.00 135.15

Diquafosol is an agonist of purinergic P2Y2 and P2Y4 receptors (EC50s = 0.1 and 0.4 µM, respectively, in calcium mobilization assays).{59982} It is selective for P2Y2 and P2Y4 receptors over P2Y6 receptors (EC50 = 20 µM). Ocular application of diquafosol (0.1 and 1% w/v) induces the release of mucin-like glycoproteins from rabbit conjunctival goblet cells, as well as reduces desiccation-induced corneal damage in a rabbit model of dry eye disease.{59983} Formulations containing diquafosol have been used in the treatment of dry eye disease.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • uridine 5?-(pentahydrogen tetraphosphate), P????5?-ester with uridine, tetrasodium salt
  • Correlated keywords
    • 59985-21-6 DIQUAS INS 365 KPY998
  • Product Overview:
    Diquafosol is an agonist of purinergic P2Y2 and P2Y4 receptors (EC50s = 0.1 and 0.4 µM, respectively, in calcium mobilization assays).{59982} It is selective for P2Y2 and P2Y4 receptors over P2Y6 receptors (EC50 = 20 µM). Ocular application of diquafosol (0.1 and 1% w/v) induces the release of mucin-like glycoproteins from rabbit conjunctival goblet cells, as well as reduces desiccation-induced corneal damage in a rabbit model of dry eye disease.{59983} Formulations containing diquafosol have been used in the treatment of dry eye disease.

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