Interleukin-6 Monoclonal Antibody

Interleukin-6 Monoclonal Antibody

CAT N°: 33947
Price:

168.00 142.80

IL-6 is a cytokine with roles in both the initiation and resolution of inflammatory responses.{46747,46748} IL-6 is produced in response to an inflammatory event, induces recruitment of neutrophils to the site of inflammation, and signals through the membrane-bound IL-6 receptor (IL-6R) to upregulate the synthesis of acute phase proteins, lipolysis in the liver, and induced differentiation of T and B cells. Following initiation of this classical signaling pathway, a soluble form of IL-6R (sIL-6R) is released from neutrophils to promote recruitment of monocytes and macrophages, induction of fever via IL-6 action in the hypothalamus, and production of anti-inflammatory M2 macrophages to initiate tissue repair. Production of IL-6 is dysregulated in various chronic inflammatory diseases, including rheumatoid arthritis, Castleman disease, polymyalgia rheumatica, and giant cell arteritis.{46749} It also induces tumor growth and metastasis via activation of JAK/STAT signaling.{46750} Cayman’s Interleukin-6 Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The predicted size of IL-6 is 24 kDa and this antibody recognizes IL-6 at an observed band size of 30 kDa from human samples.

We also advise you

TAF 10 Peptide

TAF 10 Peptide

TAF10 is one of many protein factors or coactivators associated with RNA polymerase II activity.{16903} One vial of this peptide...

€191.00
View