NVS-ZP7-4

NVS-ZP7-4

CAT N°: 33773
Price:

From 92.00 78.20

NVS-ZP7-4 is an inhibitor of the zinc transporter SLC39A7 (ZIP7).{62162} It induces apoptosis in TALL-1 human T cell acute lymphoblastic leukemia cells, an effect that can be reduced by expression of the ZIP7 point mutant ZIP7V430E. NVS-ZP7-4 (20 µM) increases endoplasmic reticulum, but not cytosolic, zinc levels in U2OS cells. It inhibits ferroptosis induced by erastin (Item No. 17754) in MDA-MB-231 and RCC4 cells when used at a concentration of 10 µM.{62163}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 1-[(2S)-2-[(6-fluoro-2-benzothiazolyl)amino]-3-phenylpropyl]-spiro[piperidine-4,4?(1?H)-quinazolin]-2?(3?H)-one
  • Correlated keywords
    • NVSZP74 NVSZP7 ZP74 ZIP-7 SLC39-A7 SLC-39A7 TALL1 MDAMB231 MDAMB MB231 RCC-4 U-2 OS
  • Product Overview:
    NVS-ZP7-4 is an inhibitor of the zinc transporter SLC39A7 (ZIP7).{62162} It induces apoptosis in TALL-1 human T cell acute lymphoblastic leukemia cells, an effect that can be reduced by expression of the ZIP7 point mutant ZIP7V430E. NVS-ZP7-4 (20 µM) increases endoplasmic reticulum, but not cytosolic, zinc levels in U2OS cells. It inhibits ferroptosis induced by erastin (Item No. 17754) in MDA-MB-231 and RCC4 cells when used at a concentration of 10 µM.{62163}

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