BAY-1895344

BAY-1895344

CAT N°: 33603
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From 136.00 115.60

BAY-1895344 is an inhibitor of ataxia-telangiectasia and Rad3-related protein/kinase (ATR; IC50 = 0.007 µM).{61354,61355} It is selective for ATR over DNA protein kinase (DNA-PK), ataxia-telangiectasia mutated kinase (ATM), and PI3K? (IC50s = 0.332, 1.42, and 3.27 µM, respectively).{61354} BAY-1895344 inhibits proliferation of HT-29 and LoVo colorectal cancer cells and SU-DHL-8 B lymphoma cells with IC50 values of 0.16, 0.071, and 0.009 µM, respectively. It reduces tumor growth in a mutant ATMK1964E-containing SU-DHL-8 mouse xenograft model when administered at a dose of 50 mg/kg. BAY-1895344 is synergistic with carboplatin (Item No. 13112), olaparib (Item No. 10621), or radiation in various mouse xenograft models.{61354,61355}

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