ASLAN003

ASLAN003

CAT N°: 33516
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From 66.00 56.10

ASLAN003 is an inhibitor of dihydroorotate dehydrogenase (DHODH; IC50 = 35 nM).{57586} It inhibits the proliferation of MOLM-14 and KG-1 acute myeloid leukemia (AML) cells (IC50s = 0.582 and 0.382 µM, respectively), as well as induces apoptosis in the same cells when used at concentrations of 0.5 and 1 µM. ASLAN003 (1, 2, and 4 µM) induces differentiation in bone marrow cells isolated from patients with AML or myelodysplastic syndrome (MDS). It improves survival in a patient-derived xenograft (PDX) mouse model of AML when administered at a dose of 50 mg/kg.

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