Flufenamic Acid-d<sub>4</sub>

Flufenamic Acid-d4

CAT N°: 33272
Price:

From 237.00 201.45

Flufenamic acid-d4 is intended for use as an internal standard for the quantification of flufenamic acid (Item No. 21447) by GC- or LC-MS. Flufenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 3 and 9.3 µM for human COX-1 and COX-2, respectively).{8427} Flufenamic acid inhibits TNF-?-induced increases in COX-2 levels and NF-?B activation in HT-29 colon cancer cells in a concentration-dependent manner.{8510} It inhibits calcium influx induced by fMLP (fMLF; Item No. 21495) or A23187 (Item No. 11016) in human polymorphonuclear leukocytes (PMN) with IC50 values of 29 and 14 µM, respectively.{1819} Flufenamic acid also activates various ion channels, including transient receptor potential canonical 6 (TRPC6) and the large-conductance calcium-activated potassium channel (KCa1.1).{60389} It also inhibits various ion channels, including TRPC3 and the cystic fibrosis transmembrane conductance regulator (CFTR). Flufenamic acid (20 mg/kg) reduces increases in intestinal fluid secretion and intestinal barrier disruption in mice infected with the El Tor variant of V. cholerae.{60390}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 2-[[3-(trifluoromethyl)phenyl]amino]-benzoic acid-d4
  • Correlated keywords
    • deuterated deuterium GCMS LCMS NSC 82699 NSC 219007 NSC82699 NSC219007 CI-440 CI440 nonsteroidal antiinflammatory COX1 TNF? COX2 NF?B HT29 f-MLP MLF A-23187 TRPC-6 3 Vibrio
  • Product Overview:
    Flufenamic acid-d4 is intended for use as an internal standard for the quantification of flufenamic acid (Item No. 21447) by GC- or LC-MS. Flufenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 3 and 9.3 µM for human COX-1 and COX-2, respectively).{8427} Flufenamic acid inhibits TNF-?-induced increases in COX-2 levels and NF-?B activation in HT-29 colon cancer cells in a concentration-dependent manner.{8510} It inhibits calcium influx induced by fMLP (fMLF; Item No. 21495) or A23187 (Item No. 11016) in human polymorphonuclear leukocytes (PMN) with IC50 values of 29 and 14 µM, respectively.{1819} Flufenamic acid also activates various ion channels, including transient receptor potential canonical 6 (TRPC6) and the large-conductance calcium-activated potassium channel (KCa1.1).{60389} It also inhibits various ion channels, including TRPC3 and the cystic fibrosis transmembrane conductance regulator (CFTR). Flufenamic acid (20 mg/kg) reduces increases in intestinal fluid secretion and intestinal barrier disruption in mice infected with the El Tor variant of V. cholerae.{60390}

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