Baloxavir Marboxil

Baloxavir Marboxil

CAT N°: 33214
Price:

From 165.00 140.25

Baloxavir marboxil is a prodrug form of the antiviral and influenza virus cap-dependent endonuclease (CEN) inhibitor baloxavir acid.{58306,58307} It inhibits influenza CEN and CEN/RNA-dependent RNA polymerase (CEN/RdRp) activity in cell-free assays (IC50s = 530 and 340 nM, respectively).{58307} Baloxavir marboxil prevents mortality in a mouse model of influenza A and B viral infection when administered at a dose of 5 or 50 mg/kg twice in a single day.{58306} It also reduces lung viral titers, body weight loss, and mortality in a mouse model of influenza A and B viral infection when administered 72 hours post-infection at 50 mg/kg. Formulations containing baloxavir marboxil have been used in the early treatment of uncomplicated influenza.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • [[(12aR)-12-[(11S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-3,4,6,8,12,12a-hexahydro-6,8-dioxo-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazin-7-yl]oxy]-carbonic acid, methyl ester
  • Correlated keywords
    • Xofluza S033188
  • Product Overview:
    Baloxavir marboxil is a prodrug form of the antiviral and influenza virus cap-dependent endonuclease (CEN) inhibitor baloxavir acid.{58306,58307} It inhibits influenza CEN and CEN/RNA-dependent RNA polymerase (CEN/RdRp) activity in cell-free assays (IC50s = 530 and 340 nM, respectively).{58307} Baloxavir marboxil prevents mortality in a mouse model of influenza A and B viral infection when administered at a dose of 5 or 50 mg/kg twice in a single day.{58306} It also reduces lung viral titers, body weight loss, and mortality in a mouse model of influenza A and B viral infection when administered 72 hours post-infection at 50 mg/kg. Formulations containing baloxavir marboxil have been used in the early treatment of uncomplicated influenza.

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