Cytarabine-<wbr/><sup>13</sup>C<sub>3</sub>

Cytarabine-13C3

CAT N°: 28805
Price:

€396.00 €336.60

Cytarabine-13C3 (ara-C-13C3) is intended for use as an internal standard for the quantification of ara-C (Item No. 16069) by GC- or LC-MS. Ara-C is a nucleoside analog and prodrug form of the DNA polymerase inhibitor ara-CTP.{48724} It is triphosphorylated to ara-CTP by the successive actions of deoxycytidine kinase, deoxycytidylate kinase, and nucleoside diphosphate kinase.{48725} Ara-C inhibits proliferation of HL-60, ML-1, Raji, and Jurkat human leukemia cell lines with IC50 values of 37, 17, 16, and 72 nM, respectively.{48726} It induces cell cycle arrest at the G0/G1 phase in HL-60 cells when used at concentrations of 2.5 and 15 µM.{48724} Ara-C (75 mg/kg per day, i.p.) reduces tumor growth and increases tumor caspase-3 activity in an MOLM-13 mouse xenograft model.{48727} It also increases survival and reduces brain herpesvirus titers in infected rats when administered subcutaneously at doses of 80 and 320 mg/kg.{48728} Formulations containing ara-C have been used in the treatment of acute myeloid leukemia.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 4-amino-1-?-D-arabinofuranosyl-2(1H)-pyrimidinone-4,5,6-13C3
  • Correlated keywords
    • GCMS LCMS araC anti viral NSC 63878 NSC63878 287459 NSC287459 U-19920A U19920A 19920 A Arabino furanosyl cytosine
  • Product Overview:
    Cytarabine-13C3 (ara-C-13C3) is intended for use as an internal standard for the quantification of ara-C (Item No. 16069) by GC- or LC-MS. Ara-C is a nucleoside analog and prodrug form of the DNA polymerase inhibitor ara-CTP.{48724} It is triphosphorylated to ara-CTP by the successive actions of deoxycytidine kinase, deoxycytidylate kinase, and nucleoside diphosphate kinase.{48725} Ara-C inhibits proliferation of HL-60, ML-1, Raji, and Jurkat human leukemia cell lines with IC50 values of 37, 17, 16, and 72 nM, respectively.{48726} It induces cell cycle arrest at the G0/G1 phase in HL-60 cells when used at concentrations of 2.5 and 15 µM.{48724} Ara-C (75 mg/kg per day, i.p.) reduces tumor growth and increases tumor caspase-3 activity in an MOLM-13 mouse xenograft model.{48727} It also increases survival and reduces brain herpesvirus titers in infected rats when administered subcutaneously at doses of 80 and 320 mg/kg.{48728} Formulations containing ara-C have been used in the treatment of acute myeloid leukemia.

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