A-867744

A-867744

CAT N°: 32974
Price:

From 182.00 154.70

A-867744 is a positive allosteric modulator of ?7 nicotinic acetylcholine receptors (nAChRs).{52986} It is selective for ?7 nAChRs over ?3?2- or ?4?2 subunit-containing nAChRs (IC50s = 0.023, 19.5 and 6.4 µM, respectively) and the serotonin (5-HT) receptor subtype 5-HT3A (Ki = >30 µM). A-867744 potentiates ACh-induced currents in Xenopus oocytes expressing human ?7 nAChRs (EC50 = ~1 µM). In vivo, A-867744 (0.1-10 ?mol/kg, i.p.) improves sensory gating deficits in a paired auditory stimulus paradigm in mice.{52987}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 4-[5-(4-chlorophenyl)-2-methyl-3-(1-oxopropyl)-1H-pyrrol-1-yl]-benzenesulfonamide
  • Correlated keywords
    • A867744 ?-7 ?3-?2 ?3?-2 3?2 4?2 5HT
  • Product Overview:
    A-867744 is a positive allosteric modulator of ?7 nicotinic acetylcholine receptors (nAChRs).{52986} It is selective for ?7 nAChRs over ?3?2- or ?4?2 subunit-containing nAChRs (IC50s = 0.023, 19.5 and 6.4 µM, respectively) and the serotonin (5-HT) receptor subtype 5-HT3A (Ki = >30 µM). A-867744 potentiates ACh-induced currents in Xenopus oocytes expressing human ?7 nAChRs (EC50 = ~1 µM). In vivo, A-867744 (0.1-10 ?mol/kg, i.p.) improves sensory gating deficits in a paired auditory stimulus paradigm in mice.{52987}

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