(S)-WAY-100135 (hydrochloride)

(S)-WAY-100135 (hydrochloride)

CAT N°: 32851
Price:

From 102.00 86.70

(S)-WAY-100135 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT1A (IC50 = 15.5 nM in a radioligand binding assay using rat hippocampus).{58220} It is selective for 5-HT1A over 5-HT1B, 5-HT1C, and 5-HT2 receptors, as well as dopamine D1 and D2, and ?1-, ?2-, and ?-adrenergic receptors (IC50s = >1 µM for all).{58219} (S)-WAY-100135 (10 mg/kg) increases the number of entries into and percentage of time spent in the open arms of the elevated plus maze in mice, indicating anxiolytic-like activity.{58219}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (?S)-N-(1,1-dimethylethyl)-4-(2-methoxyphenyl)-?-phenyl-1-piperazinepropanamide, dihydrochloride
  • Correlated keywords
    • 133025-53-3 5HT 1A SWAY100135 1B 1C T2 ?1adrenergic ?2adrenergic ?adrenergic +WAY100135 (+)-WAY
  • Product Overview:
    (S)-WAY-100135 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT1A (IC50 = 15.5 nM in a radioligand binding assay using rat hippocampus).{58220} It is selective for 5-HT1A over 5-HT1B, 5-HT1C, and 5-HT2 receptors, as well as dopamine D1 and D2, and ?1-, ?2-, and ?-adrenergic receptors (IC50s = >1 µM for all).{58219} (S)-WAY-100135 (10 mg/kg) increases the number of entries into and percentage of time spent in the open arms of the elevated plus maze in mice, indicating anxiolytic-like activity.{58219}

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