15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F<sub>2?</sub>

15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2?

CAT N°: 32791
Price:

From 146.00 124.10

15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2? (15-(6-nitroxyhexanoyl)-17-phenyl trinor PGF2?) is a nitric oxide-donating derivative of 17-phenyl trinor PGF2? (Item No. 16810).{62159} It increases cGMP levels in rabbit aqueous humor and iris ciliary body when topically administered at a concentration of 0.042%. Topical administration of 15-(6-nitroxylhexanoyl)-17-phenyl trinor PGF2? (0.14%) reduces intraocular hypertension (IOP) in a rabbit model of hypertonic saline-induced transient ocular pressure. It also reduces IOP in a cynomolgus monkey model of laser-induced ocular hypertension when administered topically at a concentration of 0.042%.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 6-(nitrooxy)-hexanoic acid, (1S,2E)-3-[(1R,2R,3S,5R)-2-[(2Z)-7-(ethylamino)-7-oxo-2-hepten-1-yl]-3,5-dihydroxycyclopentyl]-1-(2-phenylethyl)-2-propen-1-yl ester
  • Correlated keywords
    • NCX470
  • Product Overview:
    15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2? (15-(6-nitroxyhexanoyl)-17-phenyl trinor PGF2?) is a nitric oxide-donating derivative of 17-phenyl trinor PGF2? (Item No. 16810).{62159} It increases cGMP levels in rabbit aqueous humor and iris ciliary body when topically administered at a concentration of 0.042%. Topical administration of 15-(6-nitroxylhexanoyl)-17-phenyl trinor PGF2? (0.14%) reduces intraocular hypertension (IOP) in a rabbit model of hypertonic saline-induced transient ocular pressure. It also reduces IOP in a cynomolgus monkey model of laser-induced ocular hypertension when administered topically at a concentration of 0.042%.

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