(±)5-<wbr/>HEPE

(±)5-HEPE

CAT N°: 32200
Price:

From 80.00 68.00

(±)5-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 5(S)-HEPE and 5(R)-HEPE. The biological activity of (±)5-HEPE is likely mediated by one of the individual isomers, most commonly the 5(S) isomer in mammalian systems. EPA can be metabolized to 5-HEPE in human and bovine neutrophils, and human eosinophils, which is further metabolized to 5-oxoEPE and LTB5.{11149,11166,11167} The 5-series metabolites of EPA, namely 5-HEPE, 5-oxoEPE, and LTB5, have significantly decreased biological effects compared to the arachidonic acid-derived metabolites.{11167}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (±)-5-hydroxy-6E,8Z,11Z,14Z,17Z-eicosapentaenoic acid
  • Correlated keywords
    • racemic hydroxy acids fatty EPA autoxidation (+/-)5-HEPEs eicosapentanoic (+/-)-HEPEs (+/-)HEPEs
  • Product Overview:
    (±)5-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 5(S)-HEPE and 5(R)-HEPE. The biological activity of (±)5-HEPE is likely mediated by one of the individual isomers, most commonly the 5(S) isomer in mammalian systems. EPA can be metabolized to 5-HEPE in human and bovine neutrophils, and human eosinophils, which is further metabolized to 5-oxoEPE and LTB5.{11149,11166,11167} The 5-series metabolites of EPA, namely 5-HEPE, 5-oxoEPE, and LTB5, have significantly decreased biological effects compared to the arachidonic acid-derived metabolites.{11167}

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