Gemfibrozil-d<sub>6</sub>

Gemfibrozil-d6

CAT N°: 31915
Price:

109.00 92.65

Gemfibrozil-d6 is intended for use as an internal standard for the quantification of gemfibrozil (Item No. 14835) by GC- or LC-MS. Gemfibrozil is a peroxisome proliferator-activated receptor ? (PPAR?) and PPAR? agonist (EC50s = 193.3 and 147.8 µM, respectively, in transactivation assays).{23621} In vivo, gemfibrozil (50 mg/kg, p.o.) reduces serum total cholesterol, triglyceride, and LDL levels in a rat model of high-cholesterol diet-induced hyperlipidemia.{54664} Gemfibrozil (100 mg/kg per day) reduces atherosclerotic plaque area, superoxide production, and expression of the genes encoding the NF-?B subunit p65 and chemokine (C-C) motif ligand 2 (CCL2) in ApoE-/- mice.{54665} Formulations containing gemfibrozil have been used in the treatment of high cholesterol.

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