Fc?RIIb/CD32B (human, recombinant)

Territorial Availability: Available through Bertin Technologies only in France

• Correlated keywords
  • ?Fcgr2b Fc? Chinese Ovary Hamster CD 32B AA
• Product Overview:
  Fc?RIIb, also known as CD32B, is a low-affinity IgG receptor that binds the Fc region of IgG.{57316,57317} It is composed of two immunoglobulin-like (Ig-like) extracellular domains, a transmembrane domain, and a cytoplasmic tail domain containing an immunoreceptor tyrosine-based inhibitory motif (ITIM), which is important for its signaling activity.{57317} The Fc?RIIb isoform is generated via alternative splicing and has a shorter cytoplasmic tail than the Fc?RIIa isoform, which allows the Fc?RIIb isoform to be endocytosed. Fc?RIIb is predominantly expressed on myeloid-derived cells, whereas the Fc?RIIa isoform is primarily expressed on B cells. Fc?RIIb is a co-inhibitory receptor that, when phosphorylated at the ITIM region, inhibits the activation of activating Fc?Rs on myeloid cells and of B cell receptors but can also inhibit B cell receptor activation in the absence of ITIM phosphorylation. It inhibits the pathogen clearing activity mediated by activating Fc?Rs, including reducing phagocytosis and cytokine release by myeloid cells, and reduces immune complex-mediated cellular activation, such as inhibiting B cell activation or inducing apoptosis of self-reactive B cells.{57316} A SNP in FCGR2B, the gene encoding Fc?RIIb, is associated with susceptibility to systemic lupus erythematosus (SLE), and SNPs in FCGR2B are also associated with rheumatoid arthritis and immune thrombocytopenic purpura (ITP).{57318} Cayman’s Fc?RIIb/CD32B (human, recombinant) protein can be used for binding assay applications. This protein consists of 183 amino acids and has a calculated molecular weight of 20.8 kDa. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is approximately 29 kDa due to glycosylation.